- Meeting abstract
- Open access
- Published:
Systematic review of outcome measures in trials of pediatric anaphylaxis treatment
Allergy, Asthma & Clinical Immunology volume 10, Article number: A36 (2014)
Background
Considerable heterogeneity has been observed in the selection and reporting of disease-specific pediatric outcome measures in randomized controlled trials (RCTs) [1]. This makes interpretation of results and comparison across trials challenging [2]. Outcome measures in pediatric anaphylaxis trials have never previously been systematically assessed [3]. This systematic review (SR) will identify and assess outcome measures used in RCTs of anaphylaxis treatment in children. As a secondary objective, this SR will assess the evidence for current treatment modalities for anaphylaxis in the pediatric population.
Methods
We searched MEDLINE, EMBASE, The Cochrane Library, Cochrane Central Register of Controlled Trials (CENTRAL), and CINAHL from 2001 until December 2012. We also searched websites listing ongoing trials. We included randomized and controlled trials of anaphylaxis treatment in patients 0-18 years of age. Two authors independently assessed articles for inclusion.
Results
No published studies fulfilled the inclusion criteria (Fig 1).
Search Flow Diagram
Conclusions
There is an alarming absence of RCTs evaluating the treatments for anaphylaxis in children. High quality studies are needed and are possible to design, despite the severe and acute nature of this condition. Consensus about the selection and validation of appropriate outcome measures will enhance the quality of research and improve the care of children with anaphylaxis.
Systematic review registration
CRD42012002685
References
Clarke M: Standardising outcomes for clinical trials and systematic reviews. Trials. 2007, 8: 39-10.1186/1745-6215-8-39.
Williamson PR, Gamble C, Altman DG, Hutton JL: Outcome selection bias in meta-analysis. Stat Methods Med Res. 2005, 14: 515-524. 10.1191/0962280205sm415oa.
Sinha I, Jones L, Smith RL, Williamson PR: A systematic review of studies that aim to determine which outcomes to measure in clinical trials in children. PLoS Med. 2008, 5 (4): e96-10.1371/journal.pmed.0050096.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Open Access  This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.
The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Rubin, T., Clayton, J., Adams, D. et al. Systematic review of outcome measures in trials of pediatric anaphylaxis treatment. All Asth Clin Immun 10 (Suppl 1), A36 (2014). https://doiorg.publicaciones.saludcastillayleon.es/10.1186/1710-1492-10-S1-A36
Published:
DOI: https://doiorg.publicaciones.saludcastillayleon.es/10.1186/1710-1492-10-S1-A36