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Table 1 Definition of key terms related to OIT

From: Food oral immunotherapy

Term

Definition

Sensitization

The presence of allergen-specific IgE, or reactivity to an allergen in a skin prick test or serum specific IgE (blood test)

Clinical reactivity

Symptoms of an allergic reaction following allergen ingestion

Desensitization

Increase in allergen consumption threshold in allergic patients while on therapy

Sustained unresponsiveness (remission)

Absence of clinical reactivity to an ingested food allergen at some point (e.g., weeks or months) after therapy has been discontinued and allergen has been avoided

Oral tolerance (immunological tolerance)

Typical immune response to ingested food antigens in healthy individuals that allows for ingestion of foods without adverse reactions, regardless of the length of time since food consumption

  1. IgE: immunoglobulin E
  2. Adapted from Phelps 2022 [3]
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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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