Table 3 Overall drug management of anaphylactic events
Comparator | Uniphasic (n = 109) | Non-anaphylactic biphasic (n = 7) | Biphasic (n = 22) | P value |
|---|---|---|---|---|
First reaction (n = 138) | ||||
Average number of medications | 4.193 | 4.714 | 4.591 | 0.5812 |
Epinephrine, no. (%) | 86 (78.9) | 6 (85.7) | 19 (86.4) | 0.6794 |
Epinephrine doses administered | ||||
One | 71 | 4 | 13 | |
Two | 15 | 2 | 4 | – |
Three | 0 | 0 | 1 | |
Four | 0 | 0 | 1 | |
Average total dose (mg) | 0.545 | 0.600 | 0.515 | 0.7678 |
Epinephrine auto injector, no. (%) | 32 (37.2) | 2 (33.3) | 5 (26.3) | 0.7260 |
H1 antagonist, no. (%) | 106 (97.2) | 7 (100) | 21 (95.5) | 0.8081 |
H2 antagonist, no. (%) | 67 (61.5) | 4 (57.1) | 15 (68.2) | 0.8056 |
Corticosteroid, no. (%) | 78 (71.6) | 4 (57.1) | 16 (72.7) | 0.7060 |
Beta agonist, no. (%) | 29 (26.6) | 1 (14.3) | 3 (13.6) | 0.3583 |
Average total dose (mg nebulized) | 6.39 | 5.00 | 3.93 | 0.9100 |
Intravenous fluid (IV), no. (%) | 49 (45.0) | 4 (57.1) | 10 (45.5) | 0.8223 |
IV volume (L) | 0.449 | 0.571 | 0.454 | 0.8223 |
Post-resolution medications, no. (%) | 36 (33.0) | 2 (28.6) | 7 (31.8) | 0.9673 |
Average number of post-resolution drugs | 0.449 | 0.286 | 0.364 | 0.8770 |
Second reaction (n = 29) | ||||
Average number of medications | – | 0.57 | 1.82 | 0.0289 |
Epinephrine used, no. (%) | – | 0 (0) | 4 (18.2) | – |
Epinephrine doses administered | ||||
One | 4 | |||
Two | – | – | 0 | – |
Three | 0 | |||
Four | 0 | |||
Average total dose (mg) | – | – | 0.45 | – |
H1 antagonist, no. (%) | – | 3 (42.9) | 16 (72.7) | 0.1929 |
H2 antagonist, no. (%) | – | 0 (0) | 3 (13.6) | – |
Corticosteroid, no. (%) | – | 0 (0) | 6 (27.3) | 0.3866 |
Beta agonist, no. (%) | – | 0 (0) | 2 (9.1) | – |
Average total dose (mg nebulized) | – | – | 2.7 | – |
Intravenous fluid (IV), no. (%) | – | 0 (0) | 2 (9.1) | – |
IV volume (L) | – | – | 0.05 | – |