Fig. 1
From: Shared genetic investigation of asthma and blood eosinophils in relation to chronic rhinosinusitis
Overview of this study. First, we identified the profiles of blood cell traits and asthma comorbidity in healthy controls and CRS patients. Second, we adopted genetic study including LDSC analysis to clarify the genetic correlation of paired traits, single variable and multivariable MR to estimate the causal role of blood cell traits or asthma on CRS and CRSwNP and colocalization analysis to detect the shared causal genetic signals between traits. Abbreviations: CRS, chronic rhinosinusitis; CRSwNP, CRS with nasal polyps, LDSC: linkage disequilibrium score regression; MR, Mendelian randomization; SNP, single nucleotide polymorphism