Angioedema

Table 2 Comparison of HAE and AAE [7]

	Family history	Complement levels/laboratory findings
	Family history	C4	C1-INH antigen	C1-INH function	C1q^†
HAE-1 HAE-2	Yes*	↓ ↓	↓ Normal or ↑	↓ ↓	Normal
HAE-nC1-INH	Yes	Normal	Normal	Normal	Normal
AAE	No	↓	Normal or ↓	↓	Low

*In approximately 25% of patients, no family history is identified; the disorder results from spontaneous mutation of the C1 inhibitor gene
^†C1q level testing may be difficult to obtain in Canada
Adapted from: Betschel et al. 2019 [7]

ISSN: 1710-1492