Table 1 Diagnostic criteria for AD [33,34,35]

Major criteria:

Patient must have:

· An itchy skin condition (or parental/caregiver report of scratching or rubbing in a child)

Minor criteria:

Plus three or more of the following minor criteria:

Older children/adults:

 · History of itchiness in skin creases (e.g., folds of elbows, behind the knees, front of ankles, around the neck)

 · Personal history of asthma or allergic rhinitis

 · Personal history of general dry skin in the last year

 · Visible flexural dermatitis (i.e., in the bends or folds of the skin at the elbow, knees, wrists, etc.)

 · Onset under age 2 years

Children < 4 years: *

 · History of itching of the cheeks

 · History of atopic disease in a first-degree relative

 · Eczema of cheeks, forehead and outer limbs