Therapeutic potential of the topical recombinant human interleukin-1 receptor antagonist in guinea pigs with allergic rhinitis

Table 1 Effects of topical rhIL-1Ra on ovalbumin-induced of AR symptoms on Day 49

Group	Number	Frequency/severity of symptoms within 1 h
Group	Number	Sneezing	Nose rubbing	Lacrimation	Congestion	Rhinorrhea
Control	10	2.0 ± 0.8	18.9 ± 9.2	+	-	-
Model	10	16.2 ± 5.0^Δ	62.3 ± 17.9^Δ	+++	+++	+
50 μg/kg rhIL-Ra	9	9.0 ± 1.9^*	41.6 ± 8.6^*	++	+	-
100 μg/kg rhIL-Ra	9	8.1 ± 2.4^*	38.8 ± 8.4^*	++	-	-
200 μg/kg rhIL-Ra	9	7.6 ± 1.5^*	36.0 ± 7.8^*	+	-	-
Budesonide	9	6.8 ± 2.4^*	29.5 ± 11.5^*	+	-	-

#p < 0.05, compared with the control group; *p < 0.05, compared with the model group

ISSN: 1710-1492