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Fig. 1 | Allergy, Asthma & Clinical Immunology

Fig. 1

From: Underlying IPEX syndrome in a patient with idiopathic juvenile arthritis and vitiligo

Fig. 1

Skin and pathological findings (A), familial pedigree (B) and electropherograms (C). A Vitiligo-like lesions observed in the legs and hand. Skin biopsy (left forearm), histopathological findings are: the epidermis shows parakeratosis, areas of hypogranulosis, acanthosis and mild spongiosis. The dermis exhibits a perivascular and superficial inflammatory infiltrate of lymphocytes and scattered neutrophils, as well as fibroplasia and verticalized papillary collagen fibers (hematoxylin–eosin, ×100). B Familial pedigree evidencing the affected proband in black quarter. C Electropherograms evidencing the c.1150G>A; p.Ala38Thr mutation in FOXP3 found in the affected proband and in the mother

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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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