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Fig. 7 | Allergy, Asthma & Clinical Immunology

Fig. 7

From: Anti-asthmatic miR-224-5p inhibits the FHL1/MAPK pathway to repress airway smooth muscle cell proliferation in a murine model of asthma-like airway inflammation

Fig. 7

MiR-224-5p inhibits proliferation and enhances apoptosis of ASMCs by repressing FHL1. ASMCs were transduced with miR-224-5p mimic/NC-mimic or in combination with oe-FHL1/oe-NC. A Expression of miR-224-5p and FHL1 in ASMCs determined by RT-qPCR. B ASMC proliferation examined by MTT assay. C Protein levels of cleaved PARP and cleaved caspase-3 in ASMCs measured by Western blot analysis. D Flow cytometric data showing cell cycle distribution. E Flow cytometric data showing cell apoptosis. * p < 0.05 compared with ASMCs transduced with NC-mimic. # p < 0.05 compared with ASMCs transduced with miR-224-5p-mimic + oe-NC. Cell experiments were performed in triplicate

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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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